Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing

Abstract Background Mesenchymal stromal cells (MSCs) and their extracellular vesicles (MSC-EVs) have demonstrated to elicit immunomodulatory and pro-regenerative properties that are beneficial for the treatment of chronic wounds.Thanks to different mediators, MSC-EVs have shown to play an important role in the proliferation, migration and cell surv

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Crowd flow forecasting via agent-based simulations with sequential latent parameter estimation from aggregate observation

Abstract Unlike conventional crowd simulations for what-if analysis, agent-based crowd simulations for real-time applications are an emerging research topic and an important tool for better crowd managements in smart cities.Recent studies have attempted to incorporate the real-time crowd observations into crowd simulations for real-time crowd forec

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Toward an application of automatic evaluation system for central facial palsy using two simple evaluation indices in emergency medicine

Frame Parts Abstract A stroke is a medical emergency and thus requires immediate treatment.Paramedics should accurately assess suspected stroke patients and promptly transport them to a hospital with stroke care facilities; however, current assessment procedures rely on subjective visual assessment.We aim to develop an automatic evaluation system f

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